#India #Ahmedabad #Drug Delivery #Piramal Pharma #Tablet-in-Capsule

Piramal Pharma Solutions Launches Tablet-in-Capsule Technology

Piramal Pharma Solutions, a top Contract Development and Manufacturing Organization (CDMO), has recently made significant strides in the pharmaceutical sector by introducing a new tablet-in-capsule delivery system. This move underscores Piramal's commitment to enhancing patient-centered solutions in drug delivery.

In an exciting breakthrough, the company has successfully developed, scaled up, and commercialized this innovative system at its facilities in Pithampur and Ahmedabad, India. Following a seamless technology transfer between these two sites, Piramal has reinforced its extensive technological capabilities and expertise. The collaboration between the teams showcases a profound integration of essential functions, which is pivotal in the pharmaceutical industry.

The tablet-in-capsule capability allows for a more flexible and customizable approach in administering critical oral drug therapies, particularly concerning modified release formulations. The journey toward this development began at the Piramal Pharmaceutical Development Services (PPDS) site in Ahmedabad. Remarkably, within just five months, the site team completed a successful technology transfer to the manufacturing site in Pithampur, involving extensive development efforts for three tablets to be encapsulated.

Benefits of Tablet-in-Capsule Technology

Traditional capsules typically contain a blend of active pharmaceutical ingredients (APIs) and excipients within a two-piece hard shell. Although these capsules facilitate rapid absorption and are user-friendly, they often restrict patient dosing flexibility and control, posing challenges for therapies with intricate delivery requirements.

In contrast, tablet-in-capsule technology presents an innovative approach that enables distinct formulation of different active ingredients into individual tablets or minitablets. These tablets are then housed together in a single capsule shell, significantly enhancing medication administration. By utilizing unique coatings for minitablets, pharmaceutical developers can achieve versatile release profiles, allowing them to incorporate incompatible ingredients into one capsule. This not only simplifies the dosing regimen for patients but also enhances adherence to prescribed therapies.

Dr. Brad Gold, Head of Global Formulations R&D at Piramal Pharma Solutions, commented, “By allowing dual actives within a single capsule or allowing dual-release profiles, our tablet-in-capsule technology delivers unparalleled dosing flexibility and control. This approach expedites timelines for developers while simplifying the medication experience for patients.” He further emphasized that by optimizing each active ingredient in its respective tablet, the technology supports enhanced stability of formulations and greater personalization of medicine.

A Patient-Centric Approach to Drug Development

Piramal Pharma Solutions recognizes the transformative impact that tablet-in-capsule technology has on drug product development in the pharmaceutical realm. By integrating this cutting-edge approach into its formulation services, Piramal continues to demonstrate unwavering commitment to patient-centric innovations. As healthcare continuously shifts towards more tailored solutions, such advancements are crucial for effective treatment outcomes.

Piramal Pharma Solutions stands at the forefront of this evolution, not only offering its partners enhanced solutions but also serving the broader aim of improving patient care in the global landscape. This initiative exemplifies the organization's dedication to solving contemporary challenges in the drug delivery field, thereby meeting the varied needs of patients while advancing medical standards globally.

In summary, the advent of tablet-in-capsule capabilities by Piramal Pharmaceuticals reflects a significant milestone in pharmaceutical technology, illustrating the company's unwavering commitment to innovation and enhanced patient care. With its focus on developing integrated solutions that align with patient needs, Piramal Pharma Solutions is undoubtedly paving the way toward a more effective and responsive healthcare future.