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RNA Horizons 2025: Pioneering the Future of RNA Therapeutics

The RNA Horizons Therapeutics Symposium 2025, held in the vibrant city of Palermo, Sicily, gathered a diverse group of leading scientists, clinicians, and innovators from the biotech sector to delve into the transformative advancements in RNA-based therapeutics. Building on the momentum created in 2024's event in Porto, Portugal, this three-day symposium offered a platform for discussing the latest innovations and their clinical applications, particularly in oncology, metabolic disorders, and neurodegenerative diseases.

Key Themes and Focus Areas

This year's discussions underscored the critical need for enhancing the stability and targeting capabilities of RNA agents, ranging from antisense oligonucleotides to self-amplifying RNA technologies. A significant focus was placed on bridging the gap between academic discoveries, clinical developments, and practical applications within the industry. This collaborative approach aims to catalyze the transition from theoretical research to real-world therapeutic options.

Scientific Highlights

Among the standout presentations was Professor Ernesto Guccione’s introduction of the NATURA assay, designed for high-throughput measurement of RNA delivery. Additionally, Professor Shai Rosenberg shared breakthroughs in transcriptomic modeling aimed at personalized therapy. Meanwhile, Professor Ron Weiss discussed innovative miRNA-based logic circuits engineered for precise targeting of cancer cells, enhancing the potential for tailored treatment strategies.

Moreover, Professor Ronit Satchi-Fainaro introduced 3D-bioprinted tumoroids, a groundbreaking method for cancer research that allows better modeling of tumor environments. The symposium also highlighted Professor Claudio Sette's insights on splicing dysregulation in cancer, expanding the understanding of molecular behaviors in malignant conditions. Professor Rotem Karni presented compelling findings on m⁶A-dependent RNA regulation, shedding light on regulatory mechanisms that could influence therapeutic responses.

With presentations led by other prominent figures like Professor Emanuele Buratti and Dr. Christopher Ricupero, the discussions extended beyond oncology, touching upon applications in metabolic and neurodevelopmental disorders. The event was characterized by a mutual desire to catalyze scientific advancements, showcasing the power of collaboration in the pursuit of therapeutic innovations.

Collaboration: A Catalyst for Innovation

The RNA Horizons Organizing Committee reflected on the emphasis placed on collaboration, stating, “RNA Horizons 2025 highlighted the power of scientific teamwork to accelerate RNA innovation.” This gathering demonstrated a collective commitment to progressing from foundational science to practical RNA therapies that can make a significant impact on patient care.

Looking Ahead: Munich Symposium 2026

Excitingly, the next RNA Horizons Therapeutics Symposium is scheduled to take place in Munich, Germany, in September 2026. This upcoming event promises to continue the dialogue among academia, industry representatives, and clinical researchers, further driving advancements in RNA-based medicine.

About RNA Horizons

RNA Horizons is part of a broader European initiative spearheaded by the CANCERNA consortium, backed by Horizon Europe funding, with the Hadassah Cancer Research Institute at the helm. This initiative aims to unite global leaders in RNA research to propel therapeutic development and innovation forward. For further information, you can visit www.rnahorizons.com.

With ongoing discussions and collaboration, RNA Horizons 2025 marks a significant milestone in the journey toward harnessing RNA technology for therapeutic interventions, promising a future where RNA-based treatments revolutionize patient outcomes across a variety of diseases.