Volta Labs Unveils Innovative Automated Library Preparation Solution for Genomic Sequencing

Introduction

Volta Labs, a pioneer in genomic sample preparation based in Boston, has recently launched an innovative DNA Library Preparation Application tailored for the Oxford Nanopore Technologies Ligation Sequencing Kit V14 (SQK-LSK114). This new application aims to streamline and enhance the efficiency of genomic sequencing processes, effectively catering to laboratories’ evolving needs.

The Automation Advantage

At the heart of this development is the Callisto™ Sample Prep System, which facilitates a fully automated, ligation-based library preparation method specifically optimized for the PromethION platform. This implementation emerges under the Oxford Nanopore Compatibility Program, emphasizing quality and efficiency in genomic workflows.

Benchmarking Success

Early testing and benchmarking studies affirm the system's robust capabilities. During an independent clinical evaluation conducted at the University Medical Center Utrecht (UMC Utrecht), libraries prepared using the Callisto system demonstrated an impressive output of up to 120 gigabases (Gb) from a single PromethION flow cell. Moreover, these libraries delivered exceptional diagnostic-grade variant accuracy, achieving 99.66% single nucleotide variant (SNV) recall—an important metric for genomic analysis precision.

Bert van der Zwaag, from the Department of Genetics at UMC Utrecht, remarked, "As we evaluate whole genome sequencing for routine clinical diagnostics, having a robust, automated workflow is essential. Callisto's high molecular weight DNA extraction and library preparation have provided us the consistency and throughput necessary to move towards ISO 15189 accreditation for Oxford Nanopore-based sequencing, offering variant calling accuracy comparable to our established short-read pipelines."

A Commitment to Quality

The evaluation was presented at AGBT 2026, emphasizing how Callisto's integrated high molecular weight DNA extraction and ligation-based library preparation can effectively support routine whole genome sequencing while complying with ISO 15189 standards. This commitment to excellence positions Volta Labs as a key player in the rapidly advancing field of genomics.

Thomas Bray, Vice President of Corporate Business Development at Oxford Nanopore Technologies, conveyed his enthusiasm regarding the launch, stating, "The results achieved with libraries prepared with the Callisto Sample Prep System demonstrate the high performance our platform can deliver when paired with quality sample preparation for whole genome sequencing applications. We are excited to welcome Volta Labs into our Compatible Products programme."

About Volta Labs

Founded in 2018 at MIT, Volta Labs is transforming genomic sample preparation through its cutting-edge Callisto Sample Prep System. Leveraging proprietary electrowetting technology, Callisto offers a fully automated solution for DNA and RNA extraction and library preparation applicable across all major sequencing platforms, including Illumina, Oxford Nanopore, PacBio, Element Biosciences, and Ultima Genomics. Notably, this platform reduces hands-on preparation time by up to 80%, making it an attractive option for laboratories seeking to enhance operational efficiency.

With a mission to redefine genomic workflows, Volta Labs is poised to play an influential role in the future of genomic research and clinical diagnostics. For anyone interested in advancing their genomic sequencing capabilities, exploring the offerings of Volta Labs could be a significant step towards achieving greater efficiency and accuracy in their work.

Conclusion

Volta Labs’ latest launch showcases vital advancements in genomic sample preparation technology. By facilitating a more streamlined process, laboratories can achieve robust results while adhering to stringent quality standards, opening new avenues for clinical diagnostics and research innovation. As the genomics field continues to expand, developments like those from Volta Labs will undoubtedly shape the future directions of genetic exploration and application.