#Japan #Tokyo #Ampuleur #GF Booster #Aging Skin

GF Research Generates New Insights for Aging Skin

Introduction

In a groundbreaking development, Ampuleur, a clinical solution cosmetics brand developed by Highside Co., has partnered with Plusmed, a company specializing in global skin science research. Together, they have launched a new research and development base named 'Skin Innovation Lab' that focuses on innovative skincare and hair care technologies.

Research Background

Diminished EGF Responsiveness in Aging Skin

Research has increasingly highlighted that aging skin suffers from a diminished responsiveness to epidermal growth factor (EGF). This decline disrupts the skin cell renewal cycle, which can lead to common aging signs such as wrinkles, dark spots, and dullness. Recognizing this issue, Ampuleur has discovered the synergistic effects of combining EGF with their innovative GF Booster to enhance EGF responsiveness in aged cells.

Understanding EGF

Epidermal Growth Factor (EGF) is one of the most well-known growth factors in cell biology. It is a protein naturally produced by our bodies, playing a vital role in cell proliferation and regeneration. This significance has also led to its synthetic production for use in regenerative medicine and skincare formulations. EGF acts through binding to EGF receptors (EGFR), triggering essential cellular pathways, especially in keratinocyte growth. However, with aging skin, the responsiveness to EGF significantly decreases, which impedes the signaling needed for cell regeneration.

Study Results

Synergistic Effects of Combining EGF with GF Booster

The GF Booster, derived from a type of brown algae that flourishes in the extreme conditions of the North Atlantic glaciers, is recognized for its moisturizing effects. Ampuleur has long studied the GF Booster's potential to enhance EGF responsiveness. Recent clinical trials reveal that when EGF and the GF Booster are applied together to an aging epidermal keratinocyte model, cell proliferation accelerates markedly compared to either treatment alone. This finding signifies the GF Booster's ability to revive EGF responsiveness in aged cells and suggests a synergistic potential when both are used in tandem.


Figure 1: Assessment of EGF Responsiveness Recovery in Aging Cell Models

Future Perspectives

With over 20 years of pursuing innovative approaches in aging skincare, Ampuleur is committed to integrating EGF into cosmetics efficiently. These recent discoveries reflect not only advanced component research but also an understanding of the fundamental mechanisms of skin regeneration. Ampuleur aims to utilize this knowledge in the future to offer enhanced product experiences grounded in scientific efficacy, ultimately allowing individuals to maintain their unique beauty as they age.

About Ampuleur

Ampuleur represents a culmination of expertise in beauty dermatology and aims to answer the diverse definitions of beauty in today’s world. Striving to fulfill the infinite desires for beauty, Ampuleur focuses on providing clinically functional cosmetics that offer refined quality and comfort men and women alike are looking for.

For more information, visit the official website.

Highside Co., Ltd.

Since its establishment in 2003, Highside has continuously developed advanced, high-functioning cosmetics centered around Ampuleur and offers various services across the beauty, health, and medical sectors.
Headquarters: Nakameguro 1-10-23-2F, Meguro-ku, Tokyo | President: Takashi Nezu | Founded: March 14, 2003 | Business: Planning, development, and sales of cosmetics and quasi-drugs, and consulting for beauty salon management.
URL: Highside Website