UMC Utrecht Enhances Genetic Testing with Volta Labs' Callisto System

In a significant step toward advancing genetic testing capabilities, UMC Utrecht has integrated the Callisto Sample Prep System from Volta Labs into its operations. This collaboration aims to streamline processes for Whole Genome Sequencing (WGS), a pivotal technology for prenatal and postnatal genetic testing. As one of the leading public healthcare institutions in the Netherlands, UMC Utrecht recognized the urgent need for enhanced efficiency in its testing protocols due to the surging demand for genetic tests.

According to Marcel Nelen, Head of Genome Diagnostics at UMC Utrecht, the transition from whole exome sequencing (WES) to whole genome sequencing (WGS) revealed a substantial technological gap that needed overcoming. The Callisto system is designed to address this gap by offering unparalleled automation and precision. Nelen emphasized the system’s capability, stating that clinical technicians can input 24 DNA samples at once and produce clinical-grade sequencing-ready libraries in less than three hours. This remarkable efficiency not only saves valuable time but also significantly reduces the costs associated with sequencing.

The technology behind the Callisto Sample Prep System utilizes advanced digital fluidics, which greatly enhance operational precision and temperature control during the library preparation process. Udayan Umapathi, Founder and CEO of Volta Labs, stated, "The precision temperature control and liquid manipulation capabilities of the Callisto system lead to consistently high-quality libraries for Illumina sequencing, minimizing variability and improving reliability during testing."

One of the most exciting aspects of the Callisto system is its platform-agnostic design, which allows UMC Utrecht to easily adapt to different workflows and sequencing technologies as required. This flexibility ensures that the institution is well-prepared to meet future demands in the ever-evolving field of genomics.

UMC Utrecht is set to showcase the results of their initial experiences with the Callisto system at the upcoming Advances in Genome Biology and Technology (AGBT) 2025 General Meeting. This event will serve as a critical platform for sharing insights into how the integration of state-of-the-art technology is transforming genomic testing practices.

Following the successful rollout of this innovative system, Volta Labs anticipates expanding its presence in the clinical market even further. The Callisto Sample Prep System is not only beneficial for large-scale operations but is also versatile enough for smaller clinical diagnostic and translational labs. The combination of its user-friendly interface and robust performance is set to drive innovations in clinical genomics towards greater efficiency and effectiveness.

In conclusion, the adoption of the Callisto Sample Prep System is a testament to UMC Utrecht’s commitment to providing the highest quality of care through cutting-edge technology. With this collaboration, both UMC Utrecht and Volta Labs are paving the way for advancements in genetic testing, ensuring better outcomes for patients and redefining the landscape of clinical genomics.

Topics Health)

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