#Japan #Protein Dynamics #Shinjuku #BioPhenoMA #TN-cyclon

BioPhenoMA Launches Comprehensive Contract Research Service

BioPhenoMA Inc., headquartered in Shinjuku, Tokyo, has officially launched its Contract Research Service aimed at conducting protein dynamics analysis in real biological samples. Spearheaded by CEO Daisuke Niwa, this service employs the company's proprietary technology, TN-cyclon™, which allows for ultrasensitive protein detection at levels as low as 0.1 pg/mL.

The Need for Real Sample Dynamics Analysis

In various fields such as oncology, neurodegenerative diseases, infectious diseases, and metabolic disorders, there is a pressing need for researchers to assess early molecular changes and stimulus responses directly in biological specimens. Traditional methods have encountered significant limitations, leading to challenges such as:

• - Loss of structural information during extraction, hindering the ability to differentiate between membrane-facing and lumen-facing components in exosomes.
• - Inability to evaluate localization differences due to homogenization processes.
• - Low sensitivity for trace proteins, especially in non-invasive samples like urine and saliva.

These challenges often lead researchers to expend substantial time and resources on optimizing sample handling, which can stifle scientific advancement.

BioPhenoMA’s Integrated Workflow

Drawing on accumulated knowledge from both domestic and international collaborations, BioPhenoMA has established a comprehensive workflow that converts real biological samples into a 'measurable state.' This innovative protocol includes:

• - Sample Preparation: Tailored protocols for an array of complex specimens, including blood, urine, saliva, and sputum.
• - Exosome Extraction: Accurate isolation of relevant exosome-containing fractions.
• - Localization-Preserved Fractionation: This allows the retention of localization information during the analysis process, despite the disruption of exosome structures.
• - Ultrasensitive Quantification: Utilizing TN-cyclon™, the service achieves unprecedented sensitivity using standard laboratory equipment.
• - Dynamics Analysis: Enables quantitative analysis of protein changes over time under various conditions.
• - Mechanistic Interpretation: Provides insights into localization differences and responses at the molecular level.

Applications in Research

BioPhenoMA’s service stands out particularly for:

• - Drug-induced Protein Dynamics: Quantitative tracking of protein behavior under various treatments.
• - Exosome Localization Analysis: Differentiating between membrane and lumen-specific proteins at sub-pg/mL levels.
• - Biomarker Discovery: Utilizing non-invasive samples for exploring early markers of diseases.
• - Validation Studies: Confirming candidate markers identified in proteomics through real sample testing.

Flexible Research Support

The service allows for flexibility in research objectives, offering:

• - Novel Marker Discovery: Comprehensive support from antibody selection to assay development.
• - Deep Characterization of Existing Markers: Detailed analysis of multiple markers under varying conditions.
• - Exploratory Studies with Non-invasive Samples: Facilitating the use of urine and saliva for new biomarker discovery.

Integration with Research Kits

Researchers utilizing BioPhenoMA’s TN-cyclon™ ELISA Development Kit or PD-L1 TN-cyclon™ ELISA Kit can effortlessly transition their findings into contract research projects. The company also provides technical support for protocol optimization.

Future Developments

BioPhenoMA continues to advance research infrastructure integrating sample preparation, fractionation, and dynamics analysis. In April 2026, the company will present joint findings at the ISEV2026 conference in Puerto Rico, showcasing their work in collaboration with Waseda University. This presentation aims to enhance the recognition of TN-cyclon™ technology and foster further collaborations with researchers involved in real sample analysis.

About BioPhenoMA

Founded on April 18, 2023, BioPhenoMA is a startup leveraging the TN-cyclon™ technology developed by Professor Etsuro Ito and his colleagues at Waseda University. The mission of BioPhenoMA is to create a revolutionary platform that enables everyone to easily detect trace proteins and advance the field of life sciences.

Company Info
Name: BioPhenoMA Inc.
Address: 1-22-3 Nishiwaseda, Shinjuku-ku, Tokyo
CEO: Daisuke Niwa
Website: biophenoma.com
Email: [email protected]