#USA #Boston #Volta Labs #Callisto #Twist Bioscience

Volta Labs Revolutionizes Genomic Sample Preparation

In an impressive stride towards enhancing genomic sample preparation, Volta Labs announced the launch of the Twist Fast Hyb application for the Callisto™ sample preparation system. This innovation integrates seamlessly with the existing Standard Hyb v2 application, allowing laboratories to efficiently achieve target enrichment with consistent results and same-day delivery.

The Challenge of NGS Sample Preparation

Next-generation sequencing (NGS) has become a cornerstone in genomic research and diagnostics, yet the intricacies involved in sample preparation often pose significant challenges. Enrichment of target sequences through hybrid capture is one of the most complex steps, traditionally requiring meticulous control over temperature and repetitive handling of magnetic beads. These challenges can introduce variability in results, which is particularly concerning in high-stakes environments like clinical diagnostics and genomic research.

Automating a Complicated Workflow

The Twist Fast Hyb application addresses these issues head-on by automating this labor-intensive step using Callisto’s advanced fluidic platform. Laboratories can transition from long, overnight hybridization processes to same-day sequencing workflows without increasing operational burdens. By removing manual intervention from the equation, Twist Fast Hyb enhances workflow efficiency and consistency, ultimately reducing time to results.

Udayan Umapathi, the CEO and founder of Volta Labs, emphasized the application’s significance: "The target enrichment process is among the hardest workflows to automate, where slight variations in technique can significantly affect outcomes. With Twist Fast Hyb, laboratories benefit from a fully automated workflow that mirrors manual performance while providing reliability that only automation can assure."

Performance and Quality Control

Clinical trials have demonstrated that Callisto, when integrated with the Twist Fast Hyb protocol, achieves sequencing performance comparable to traditional manual preparations. Quality control metrics—such as Fold-80, coverage uniformity, and AT/GC loss—are not only met but maintained consistently.

This automated workflow is particularly beneficial for laboratories conducting comprehensive oncology profiling, whole exome sequencing, or targeted sequencing applications. In these high-pressure settings, the demand for rapid yet accurate results is paramount, and Twist Fast Hyb allows laboratories to meet these demands effectively.

A Comprehensive Hybrid Capture Portfolio

With the introduction of the Twist Fast Hyb application, Volta Labs now offers a complete hybrid capture portfolio available on the Callisto platform. Both standard and fast hybridization techniques are accessible, providing greater flexibility for laboratories to adjust their operations according to varying scheduling and performance needs.

Emily M. Leproust, CEO and co-founder of Twist Bioscience, remarked on the expansion: "By broadening our complete hybrid capture portfolio on Callisto, we empower labs to adapt seamlessly to diverse scheduling and performance requirements. Advanced automation simplifies the adoption of high-performance target enrichment solutions, enabling customers to implement them more readily than ever before without the hassles associated with manual workflows."

Conclusion

The launch of Twist Fast Hyb marks a significant milestone in the realm of genomic applications, contributing to the ongoing evolution of NGS sample preparation methods. As laboratories increasingly rely on rapid, reliable, and automated solutions, Volta Labs positions itself as a leader in the genomics space, shaping the future of research and clinical practices. The Twist Fast Hyb application is now available on the Callisto system, representing a unified, automated solution for a spectrum of hybrid capture applications.

For more information on Volta Labs and its innovative solutions, visit www.voltalabs.com.