#USA #Milford #Waters Corporation #MALS #omniDAWN

Waters Corporation Unveils the omniDAWN Multi-Angle Light Scattering Detector

Waters Corporation has made waves in the analytical sciences sector with the launch of its state-of-the-art omniDAWN™ Multi-Angle Light Scattering (MALS) Photometer. As a pioneering product within the Wyatt Technology Portfolio, this device signifies a monumental advancement in the realm of Ultra High Performance Liquid Chromatography (UHPLC) and Ultra Performance Liquid Chromatography (UPLC).

With the capability to deliver up to four times faster chromatographic run times, the omniDAWN photometer plays a vital role in expediting decisions in discovery, development, and quality workflows, particularly for large molecules. It boasts a 10x improvement in absolute molar mass measurement and extended sizing without compromising resolution or throughput. Notably, this innovative detector allows for a 30-50% reduction in sample consumption and a 40% decrease in solvent use—critical factors in today's increasingly environmentally-conscious scientific landscape.

Enhanced Characterization of Large Molecules

The omniDAWN MALS Photometer enables a ten-fold extension of UPLC-compatible sizing. It allows the reliable characterization of larger, more complex analytes that have previously posed challenges, including protein aggregates, viral vectors, and lipid nanoparticles (LNPs). This enhanced capability is crucial for laboratories engaged in biosimilarity studies, antibody-drug conjugate (ADC) characterization, and viral vector analytics.

Rob Carpio, Senior Vice President of Waters Analytical Sciences, highlighted, “The omniDAWN MALS Photometer brings extended-range multi-angle light scattering to modern separations.” This milestone empowers customers to accelerate their research while maintaining the detection quality and consistent results vital in developing next-generation therapies.

Seamless Integration and Usability Improvements

Designed to work cohesively with Waters' UPLC systems and columns, the omniDAWN Photometer eliminates traditional compromises associated with dispersion, robustness, and analytical performance. It results in a comprehensive solution for multi-attribute characterization, simplifying workflows compared to micro-volume MALS approaches. When integrated with UHPLC or UPLC systems, this photometer not only enhances run times but also maintains the high-resolution data necessary for extensive analytical requirements. Sharper separations achieved through this device improve the detection capabilities of low-level species, which is essential for scientists to differentiate between monomers, aggregates, and fragments in complex samples.

Stacey Louie, Associate Professor at the University of Houston's Department of Civil and Environmental Engineering, emphasized the importance of this technology, stating, “Extending the capabilities of multi-angle light scattering to UHPLC and UPLC will allow for an absolute understanding of complex materials across various applications, ultimately supporting better health outcomes.”

Advanced Software to Support Analytical Needs

Powered by ASTRA™ Software, built on over four decades of light scattering innovation, the omniDAWN operates with cutting-edge detection capabilities. The software integrates MALS with ultraviolet (UV) and refractive index (RI) detection, allowing researchers comprehensive analyses of size, composition, and heterogeneity in a single run. This significant functionality equips users with specialized workflows for ADCs, LNPs, and viral vectors. Furthermore, the platform ensures compliance with 21 CFR Part 11 and EU Annex 11, with compatibility with Waters Empower™ Software expected later this year.

Conclusion

Expected to be available globally in the summer of 2026, the Waters omniDAWN MALS Photometer marks a breakthrough in analytical technology. By simplifying complex workflows and providing unparalleled capabilities for the characterization of large molecules, Waters Corporation continues to support advancements in drug discovery and development. To learn more about this innovative product or to request a demonstration, visit Waters Corporation. With such advancements, the scientific community is well on its way to achieving even greater breakthroughs in healthcare and beyond.