#United States #New England Biolabs #Ipswich #Direct RNA Sequencing #NEBNext Module

New England Biolabs Launches NEBNext Companion Module

In a move poised to revolutionize RNA research, New England Biolabs (NEB) has introduced the NEBNext Companion Module, tailored specifically for integration with Oxford Nanopore Technologies' Direct RNA Sequencing. This new product is designed to streamline the process of direct sequencing of native RNA, catering to scientists working across diverse applications where high-quality RNA sequencing is paramount.

The NEBNext Companion Module incorporates essential reagents recommended by Oxford Nanopore for the effective execution of the Direct RNA Sequencing workflow, specifically tailored for the RNA004 sequencing kit. One of its significant features is its convenient format that provides researchers with the necessary components in volumes that align with the existing protocol, ensuring consistent functionality through every stage of preparation and sequencing.

A standout element of the module is the inclusion of Induro® Reverse Transcriptase. This specially formulated enzyme plays a critical role in cDNA synthesis, effectively tackling the challenge of RNA secondary structures that can hinder sequencing efficiency. By significantly improving the passage of the RNA molecule through the nanopore, this advanced formulation is expected to boost both sequence yield and quality, a welcome enhancement for researchers eager to maximize their experimental outcomes.

Dr. Thomas Bray, VP of Corporate Business Development at Oxford Nanopore Technologies, expressed enthusiasm for this newest offering from NEB, emphasizing its role in supporting customers in implementing direct RNA workflows. He stated, "The introduction of this quality-controlled module not only streamlines the process but also enhances customers' capabilities to execute their applications effectively.”

This development arrives at a time when the scientific community is actively seeking more efficient methods to explore RNA. Traditional sequencing techniques that rely on cDNA can sometimes be limiting. The direct RNA sequencing approach, enabled by this companion module, opens up new opportunities for applications, including RNA modification identification, tRNA sequencing, and in-depth characterization of mRNAs with therapeutic potential.

Deyra Rodríguez, Ph.D., MBA, who serves as the Product Marketing Manager for NEB, highlighted the excitement surrounding this advancement. She commented, "Direct RNA sequencing presents a novel route for nucleic acid sequencing. We anticipate a surge of interest from both academic and applied markets as researchers seek to leverage this new capacity for their studies.”

The NEBNext Companion Module exemplifies NEB's commitment to advancing molecular biology research. With over 50 years of experience in the field, NEB has a long-standing legacy of developing innovative products that empower researchers. The company's dedication to scientific progress is reflected in its ongoing investment in both foundational and applied research programs, aiming to support the scientific community in academia and industry.

As NEB continues to expand its product portfolio, the NEBNext Companion Module is poised to become an essential tool in laboratories focusing on advanced RNA research. For more details and to explore the new module, you can visit www.neb.com/E3440. NEB remains steadfast in its mission to contribute positively to the well-being of employees, communities, and the planet while fostering scientific discovery.

About New England Biolabs

With its headquarters in Ipswich, Massachusetts, New England Biolabs is a privately held company that boasts a global reach through subsidiary offices in 11 countries and a vast network of over 60 distribution partners worldwide. NEB is committed to being at the forefront of molecular biology, producing innovative solutions that enhance research capabilities across various scientific fields, including cutting-edge technologies for molecular diagnostics and nucleic-acid vaccine development.

As the scientific landscape evolves, innovations such as the NEBNext Companion Module are not just enhancing current capabilities but are also paving the way for future breakthroughs in research and application within molecular biology.