TriNetX Emerges as Leading Real-World Data Source in Peer-Reviewed Research

TriNetX Becomes the Most Cited Real-World Data Source

TriNetX, a company dedicated to advancing human health through connected data and intelligence, has recently achieved significant recognition within the scientific and medical research community. As of October 15, 2025, it has been identified as the most cited source of electronic medical record data in peer-reviewed publications, according to an analysis of PubMed data up to August 27, 2025. This landmark achievement underscores TriNetX's crucial role in the evolving landscape of clinical research and data utilization.

A Surge in Citations

TriNetX has experienced an extraordinary growth of nearly 80% in citations over the past year, rising to a total of 2,025 citations. This figure astonishingly eclipses that of its closest competitor, which has received only 149 citations—demonstrating TriNetX's dominant presence in the realm of real-world evidence generation. The yearly citation figures reflect a rapid acceleration: from just 96 in 2021, the company saw citations climb to 707 in 2024. The first eight months of 2025 alone have yielded 952 citations, indicating that TriNetX is on track to exceed 1,000 citations for the first time this year.

Jeffrey Brown, PhD, the Chief Scientific Officer at TriNetX, highlighted the importance of this milestone, stating, "Researchers need to be assured that the data they use can withstand peer scrutiny and lead to meaningful results. The fact that TriNetX is now the most cited real-world dataset reflects not only our scale and quality but also the trust that the global research community places in our platform to advance science and improve patient outcomes."

Making an Impact on High-Profile Research

The influence of TriNetX data extends to prestigious medical and scientific journals such as Nature Medicine, The Journal of Allergy and Clinical Immunology, and JAMIA Open. Studies leveraging TriNetX's extensive data and state-of-the-art analytical platform are crucial in shaping new standards on how real-world data informs the clinical development of drugs and vaccines, clinical evidence production, and the safety and efficacy of patient care in the real world.

The surge in citations can be attributed to a rapid global expansion of the TriNetX LIVE™ network. Between September 2024 and September 2025, healthcare organizations and patient data on the platform reached unprecedented levels. Notably, growth was particularly strong in emerging markets, with Latin America seeing a 70% increase and the Asia-Pacific region experiencing a 31% uptick.

Steve Kundrot, Chief Operating Officer at TriNetX, remarked, "The accelerated growth of our network reflects the global interests of our clients and network partners, from drug discovery to trial design, comparative effectiveness, and care delivery. The pace of integration of health organizations and the expansion of patient data is reinforcing the power of real-world evidence worldwide, making TriNetX, with its unparalleled scale, depth, and transparency, a trusted foundation for credible research."

The Future of Real-World Data Analytics

TriNetX continues to operate the largest federated real-world data network worldwide, partnering with healthcare providers to apply insights that accelerate innovation across the healthcare ecosystem. Their self-service platform uses HIPAA, GDPR, and LGPD-compliant data sets of federated, de-identified, and anonymized electronic medical records. Through its consultancy partnerships, TriNetX enables its global community to enhance clinical trial protocol designs, streamline trial operations, refine safety signals, and enrich the production of real-world evidence.

For more insights about TriNetX and its data analytics capabilities, visit their official website and follow their latest updates on LinkedIn.

Conclusion

The ascent of TriNetX as the leading source of real-world data in peer-reviewed research is a testament to its foundational role in shaping the future of healthcare research. Its significant citation growth not only reflects the trust and reliance of the research community but also symbolizes the invaluable contribution of real-world data in pursuit of improved healthcare outcomes. As more researchers turn to TriNetX, the potential for discovering new insights and enhancing patient care continues to expand.