#Japan #mitochondria #Kumamoto #Saishunkan #Sansho Seeds

Saishunkan Pharmaceutical Unveils Groundbreaking Research

Saishunkan Pharmaceutical Co., Ltd., based in Kumamoto, has recently announced the completion of a patent application based on its research findings about sansho seed extracts. These extracts promote the expression of a significant protein called TFAM, which plays a crucial role in regenerating mitochondria—the energy-producing units within our skin cells. This innovative study has also established a potential for reducing nasolabial folds through modifying mitochondrial functionality.

The Journey to Discovery

The exploration began nine years ago in the rich natural surroundings of Okuhida, situated at an altitude of approximately 800 meters, where the aromatic sansho plants are cultivated. Initially deemed too potent for cosmetic use, a shift in perspective led Saishunkan to revolutionize the understanding of the seed's potential, which was previously discarded during food processing. This re-evaluation sparked a renewed focus on its unique properties, leading to extensive research involving over 530 plant samples.

Through this comprehensive analysis, the hydrolyzed extracts from sansho seeds exhibited a remarkable ability to enhance the expression of TFAM, thus facilitating the regeneration of mitochondria. The results indicated an increase in mitochondrial quantity and energy production while also suppressing reactive oxygen species generated by damaged mitochondria.

The Essence of Healthy Mitochondria

Aging often leads to a decline in mitochondrial performance, resulting in the overproduction of reactive oxygen species that contribute to skin aging. According to Saishunkan, merely activating aged mitochondria is not sufficient; the goal must be to increase the count of healthy mitochondria. This approach is rooted in the philosophy that restoring the skin's inherent recovery abilities is key to effective skincare solutions.

Saishunkan emphasizes that maintaining a healthy balance between the production and degradation of mitochondria through their newly discovered methods can help mitigate various aging-related skin issues, such as wrinkles, spots, and dullness.

Clinical Trials and Results

During the 71st Annual Meeting of the Japanese Society of Pharmacognosy, held from September 14th to 15th, 2025, Saishunkan’s groundbreaking findings on sansho seed hydrolysates were presented. Additionally, results from a human study demonstrated significant improvements in nasolabial folds when comparing creams formulated with sansho seed extracts against standard formulations without the ingredient. The group using the sansho-infused cream experienced notable reductions in average and maximum fold depths.

In essence, the average depth of nasolabial folds in the group using the control cream increased by approximately 10%, while the group using the sansho cream saw an 8.5% reduction.

Future Implications

The research conducted by Saishunkan aims not only to improve its flagship cosmetic product, Domohorn Wrinkle, but also to explore applications in health foods and dietary supplements. This aligns with their goal of harnessing nature's potential for human benefit through scientific innovation, making it possible to extend the lifespan of healthy skin and overall wellbeing.

The exploration of sansho seed extracts showcases Saishunkan's unique approach that marries traditional herbal philosophy with cutting-edge scientific research, reimagining natural resources into viable solutions for age-related skin concerns.

Commitment to Sustainability

In addition to their research on sansho seeds, Saishunkan’s work with Shiranui Chrysanthemum showcases their dedication to sustainable practices in herb production. By collaborating with local farmers and promoting stable cultivation, the company is responsive to both ecological needs and community health, highlighting the broader benefits of their initiatives.

As they prepare to celebrate their anniversary in 2032, Saishunkan Pharmaceutical remains focused on uncovering the mechanisms behind aging while adhering to the principle of fostering a sustainable future that connects people and nature. Their innovative solutions reflect a commitment to not only enhancing skin vitality but also nurturing the communities around them.