FIU Researchers Innovate CAR-T Therapy to Extend Immune Cell Longevity and Effectiveness in Cancer Treatment
Enhancing the Efficacy of CAR-T Therapy
Researchers at Florida International University (FIU) have uncovered a groundbreaking technique to boost the performance of CAR-T therapy, a powerful cancer treatment that utilizes genetically modified T-cells from patients' own immune systems. This innovative approach aims to address a critical obstacle in oncology: the survivability of immune cells that often diminishes in the hostile tumor microenvironment.
Car-T therapy has shown promise in treating various blood cancers, including lymphoma and leukemia, by removing T-cells from patients, genetically modifying them to identify and attack cancer cells, and reintroducing them into the body. However, the effectiveness of this treatment is limited when tumors create a protective barrier that hampers the activity of these engineered immune cells.
In a significant advance, FIU scientists, led by Professor Charles Dimitroff, employed a method known as glycoengineering to fortify CAR-T cells with a specialized
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