Navinci Unveils Innovative Naveni® Plex Omni Service for Spatial Interactomics Research

In an exciting advancement for scientific research, Navinci has officially launched its Naveni® Plex Omni Service. This innovative service is designed to provide researchers with unprecedented access to spatial interactomics, facilitated by the company’s proprietary multiplex in situ proximity ligation assay technology, known as misPLA.

The Naveni® Plex Omni Service empowers scientists to map protein functions and their interactions within a spatial framework. This capability is vital for gaining deeper insights into fundamental biological processes, the progression of diseases, and improving predictions regarding treatment outcomes. The platform enables the simultaneous detection of up to eight protein interactions, individual proteins, or specific phosphorylation states within human formalin-fixed, paraffin-embedded (FFPE) samples.

One of the groundbreaking applications of the Naveni® Plex technology is its ability to decode complex biological phenomena, such as tumor-stroma interactions, functional states of immune cells, and the molecular mechanisms that drive treatment responses. Specifically, this technology is pivotal in understanding why certain cancers manage to evade immune detection, as well as the diverse responses seen in patients undergoing immunotherapy.

The unique misPLA technology harnesses the power of antibody-oligonucleotide pairs that yield amplifiable DNA when they bind closely together. This mechanism allows for the precise detection of protein interactions and modifications, making it effective even for rare or transient targets that are otherwise difficult to study.

For the first time, Navinci is offering a service that allows researchers to utilize this cutting-edge technology without getting bogged down in the technical optimizations. The assays are run by the same experts who developed the technology, allowing researchers to concentrate on their findings rather than the intricacies of assay execution.

The Naveni® Plex Omni Service guarantees a streamlined process, providing support from panel design all the way to data delivery. Researchers can opt for custom 4-8-plex panels created from validated targets, or choose from an array of pre-validated options covering critical research areas including MAPK signaling, immuno-oncology, and T-cell receptor (TCR) or B-cell receptor (BCR) profiling.

Additionally, a proof-of-concept study conducted in collaboration with Uppsala University has already demonstrated the utility of this service and has been published on BioRxiv, emphasizing the relevance and potential of this innovative approach in advancing scientific research.

For further details on the Naveni® Plex Omni Service, interested researchers are encouraged to contact Jenny Sundqvist, CEO, or visit the Navinci website for scientific information and panel design assistance. This pioneering service stands to revolutionize spatial interactomics, providing researchers with the tools needed to unlock new biological insights that could lead to significant advances in disease understanding and treatment strategies.