#USA #Milford #Waters Corporation #Xevo TQ Absolute XR #Mass Spectrometer

Waters Corporation Unveils the New Xevo TQ Absolute XR Mass Spectrometer

On June 2, 2025, Waters Corporation made a significant announcement at the 73rd ASMS Conference on Mass Spectrometry and Allied Topics regarding the launch of their latest innovation—the Xevo™ TQ Absolute XR Mass Spectrometer. This cutting-edge device is designed to cater to the needs of high-throughput laboratories, offering enhanced sensitivity and robustness that set a new standard in the industry.

The Xevo TQ Absolute XR is touted as the most sensitive and reliable benchtop tandem quadrupole mass spectrometer currently available, surpassing the already impressive Xevo TQ Absolute. With advancements in performance capabilities, especially for applications like pharmaceutical quantitation and PFAS detection, the new device is engineered for demanding environments such as pharmaceutical companies, contract testing organizations, and government laboratories. It promises exceptional performance for trace-level analyses, optimizing system uptime and operational efficiency.

Significant Improvements in Performance

One of the standout features of the Xevo TQ Absolute XR is its performance robustness, which has been enhanced by up to six times compared to its predecessor. The device utilizes the innovative StepWave™ XR Ion Guide technology, which minimizes the risk of unexpected downtimes while preserving the sensitivity and accuracy required for analyzing complex samples and fragile compounds.

This system is particularly timely as labs face increasing pressures from pharmaceutical organizations needing to navigate the evolving regulatory landscape surrounding PFAS testing. As James Hallam, Vice President of Liquid Chromatography-Mass Spectrometry at Waters Corporation, emphasized: "Analytical laboratories are under pressure to adapt to the complex needs of pharmaceutical organizations and meet the increasing demand for PFAS testing driven by a rapidly evolving regulatory landscape.”

Efficiency on Multiple Levels

In addition to its performance enhancements, the Xevo TQ Absolute XR is remarkably energy-efficient. The product reportedly uses up to 50% less power and gas than comparable high-performing tandem or triple quadrupoles, producing 50% less heat and requiring 50% less bench space. This aligns perfectly with the growing trend of reducing environmental footprints within laboratory settings without sacrificing throughput and performance.

Furthermore, the Xevo TQ Absolute XR provides unparalleled capabilities for the quantification of negatively ionizing compounds, such as PFAS. The device also supports a variety of applications including bioanalysis, food safety, and environmental testing, offering laboratory clients high-confidence results and efficiency gains that are critically important in today’s fast-paced research environment.

Proven Results in Real World Scenarios

Sally Hannam, Scientific Director of Synexa Life Sciences, shared her experience with the Xevo TQ Absolute XR, stating: "Our laboratory requires instrumentation that delivers high-quality, interruption-free results to our customers, helping them to bring safe and effective new drugs to market with confidence and speed.” Her team has already performed over 20,000 injections of crashed human plasma continuously analyzed using this new mass spectrometer combined with the ACQUITY™ Premier UPLC™ System. Her early observations reveal that the instrument showcases new levels of reproducibility and accuracy, essential for tackling increasingly challenging bioanalytical applications.

With the Xevo TQ Absolute XR, Waters Corporation continues its legacy of innovation in analytical instruments, with the aim of enhancing safety, quality, and efficiency in laboratories worldwide. The device is currently available for order, symbolizing a crucial step forward in analytical science.

Conclusion

The launch of the Xevo TQ Absolute XR Mass Spectrometer marks an important milestone in analytical technology, providing laboratories with the tools needed to meet modern challenges in pharmaceutical development and compliance testing. As Waters Corporation remains at the forefront of this technological evolution, the Xevo TQ Absolute XR represents a significant leap in achieving higher standards of efficiency and reliability in laboratory analysis.