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DuPont Unveils the AmberChrom TQ1 Chromatography Resin

DuPont, a global leader in innovation, has expanded its bioprocessing portfolio with the recent launch of the DuPont™ AmberChrom™ TQ1 chromatography resin. This new product is designed specifically for the purification of oligonucleotides and peptides, pivotal in the biopharmaceutical field.

According to Shane Kendra, Global Bioprocessing Market Leader at DuPont Water Solutions, the introduction of the AmberChrom TQ1 resin aims to expedite the development and commercialization process for therapies involving oligonucleotides and peptides. He emphasized that this new anion exchange chromatography resin not only broadens the company's capabilities but also sets a benchmark for exceptional performance within its product category.

Features and Benefits

The awe-inspiring characteristics of AmberChrom TQ1 include:

• - Increased Loading Capacity: This enables higher throughput during purification processes.
• - Lower Pressure Requirements: Compared to competing products, this resin demands less pressure, making it easier to use in various contexts.
• - High Resolution Separations: Capable of delivering high purity fractions during biomolecule purifications, it effectively segregates closely related impurities from target molecules.
• - Adaptability for Large Scale Use: The resin's design accommodates both benchtop and commercial-scale purifications, qualifying it for a broad range of applications.

Focused on maximizing purification efficacy, AmberChrom TQ1 is especially suitable for working with DMT-Off and DMT-On oligonucleotides and boasts a low-pressure build-up that enhances its performance further.

As part of the resin's rollout, DuPont has conducted extensive internal application studies employing real-world drug feeds to affirm its effectiveness. These studies are pivotal in assisting organizations looking to integrate the resin into their workflows, spanning from drug discovery all the way to commercialization.

Commitment to Customer-Centric Solutions

DuPont's ongoing commitment to refining its bioprocessing portfolio is a testament to its desire to be a one-stop solution for the purification and polishing of critical biomolecules. Shane Kendra noted, "Our technical teams and scientists perpetually engage with clients to develop efficient bioprocessing solutions tailored for every phase of the drug development process."

The AmberChrom TQ1 resin is designed to complement existing DuPont chromatography resins, such as AmberChrom XT and CG, allowing for the purification of diverse oligonucleotide feeds as well as crude purification of peptide feeds in preparation for reverse phase chromatography.

DuPont's unveiling of this chromatography resin occurred at the TIDES USA conference, an event dedicated to the advancement of oligonucleotide and peptide innovations. During the event, Dr. Hadi Fares, a bioprocessing application scientist, presented significant application studies that highlighted how the AmberChrom TQ1 resin enhances the existing DuPont bioprocessing offerings.

Upcoming Educational Webinar

To further engage with stakeholders interested in this revolutionary product, DuPont will host an educational webinar on June 19, 2025. This session will discuss the capabilities and benefits of the AmberChrom TQ1 chromatography resin, emphasizing its loading capacity and purification efficiency that can notably elevate the purification processes for oligonucleotides and peptides. Interested individuals can register for the webinar through the DuPont website.

As a pioneer with over 80 years of experience in the field of adsorbents and ion exchange resins, DuPont's bioprocessing solutions facilitate the rapid discovery and production of essential therapeutics. Through complicated separations and innovative approaches, the company aids partners in tackling some of the most pressing health challenges of our time.

Explore more about DuPont™ AmberChrom™ TQ1 chromatography resin and its broader bioprocessing portfolio by visiting the DuPont website.