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Upcoming Webinar on Anti-Drug Antibody Detection

In the field of biopharmaceuticals, Antibody-Drug Conjugates (ADCs) represent a groundbreaking advancement, paving the way for more effective therapies. However, these innovations are not without their challenges, particularly in the realm of bioanalytical testing. A free webinar presented by Xtalks is set to delve into the intricate issues surrounding anti-drug antibody detection for ADCs, offering valuable insights for industry professionals.

Understanding the Importance of ADCs

ADCs combine the targeted therapy of antibodies with the cell-killing ability of drugs, creating treatments that are both effective and potentially less harmful than traditional chemotherapy. Despite their promise, the unique structure of ADCs can complicate bioanalytical processes. One of the major hurdles in this aspect is the presence of pre-existing antibodies, which can interfere with the accurate detection of treatment-boosted anti-drug antibodies (ADAs).

Webinar Highlights

In this engaging session, attendees will learn about various methods to mitigate the impact of pre-existing antibodies on assay validation and cut-point determination. The featured expert will share real-world case studies that illustrate these challenges and solutions. For example, a significant case involved a humanized single-chain antibody linked to a bacterial toxin, where it was discovered that 90% of naive donor samples contained varying levels of pre-existing antibodies. This realization was crucial for adjusting the assay approach.

Key Takeaways

The webinar will cover:

• - Method Validation Strategies: Understanding alternatives for method validation and how to determine cut-points effectively.
• - Impact of Pre-existing Antibodies: Insights on how these antibodies affect various testing tiers and the overall detection process.
• - Real-World Strategies: Lessons learned from clinical sample analysis and practical strategies for addressing high rates of pre-existing antibodies.

Register for the Webinar

The session is scheduled for Wednesday, September 24, 2025, at 10 AM EDT. It will provide a platform for professionals from the pharmaceutical, biotechnology, and healthcare sectors to enhance their understanding and skills in bioanalytical testing.

With guidance from Martin Roberge, PhD, Director of Development Innovation at the Bioanalytical Center of Excellence, this event promises to be both informative and engaging.

About Xtalks

Xtalks is well-known for its quality educational content across various industries, focusing on the life sciences, food, healthcare, and medical devices. This platform empowers professionals by providing access to insights and knowledge necessary to keep pace with emerging trends and challenges in their respective fields.

For further details and registration, visit Xtalks. Don't miss this opportunity to refine your skills and knowledge around ADC analysis and the complexities involved in anti-drug antibody detection.