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Piramal Pharma Solutions Introduces Tablet-in-Capsule Technology

Piramal Pharma Solutions, a renowned Contract Development and Manufacturing Organization (CDMO), has recently demonstrated its commitment to advanced drug delivery systems by successfully developing and marketing a tablet-in-capsule product at its facilities in Pithampur and Ahmedabad, India. This innovation not only emphasizes the company's leadership in this sector but also solidifies its dedication to patient-centric solutions.

Strategic Development Process

The development project for the tablet-in-capsule system was initiated at the Piramal Pharmaceutical Development Services (PPDS) site in Ahmedabad. Within a remarkably short timeframe of five months, the project teams achieved a successful technology transfer to the commercial production site in Pithampur, completing the encapsulation of three distinct tablet formulations. This rapid progression highlights the efficiency of Piramal’s integrated approach—leveraging its extensive technological capabilities and knowledge across different sites.

According to Dr. Brad Gold, who heads the Global Research and Development department at Piramal Pharma Solutions, the seamless collaboration between the teams at both locations was critical for overcoming challenges during the transition and ensuring that the product met the strictest quality and regulatory standards. This collaboration has enabled the company to offer innovative therapeutic options to patients who rely on these medications.

Revolutionizing Oral Dosage Forms

Traditional capsule formats include a mixture of Active Pharmaceutical Ingredients (API) contained within a hard shell, which can limit flexibility in dosage customization for more complex therapies. This is where the tablet-in-capsule technology shines. By encapsulating separate tablets or mini-tablets within a single capsule, the technology allows pharmaceutical developers to achieve varied release profiles for the active ingredients.

Moreover, this method facilitates the combination of incompatible drugs within the same capsule, simplifying the medication regimen for patients and enhancing adherence to prescribed therapies. The technology responds to the rising demand for tailored medication solutions in today’s healthcare landscape.

Unique Advantages and Future Directions

The tablet-in-capsule approach provides unparalleled control over dosage and release characteristics, thereby enabling quicker developmental timelines for new therapies. Each medication can be optimized within its respective tablet form, which not only enhances the formulation's stability but also personalizes the treatment experience for patients.

As pharmaceutical companies strive to meet diverse patient needs, Piramal’s integration of tablet-in-capsule technology into its existing portfolio not only reflects the company’s patient-first ethos but also reaffirms its pivotal role as a leader in pharmaceutical innovation.

Piramal Pharma Solutions continues to expand its array of end-to-end services for drug lifecycle management, reinforcing its commitment to delivering superior solutions that tackle the evolving challenges in drug delivery.

About Piramal Pharma Solutions

Piramal Pharma Solutions provides comprehensive development and manufacturing solutions throughout the entire lifecycle of pharmaceuticals. With a global network that spans North America, Europe, and Asia, it delivers a range of services that includes drug research, process development, clinical trial support, and commercial production of APIs and finished dosage forms. Furthermore, specialized services such as the development and manufacturing of complex APIs underscore its expertise and leadership in the pharma sector.

With an emphasis on innovation and quality, Piramal Pharma Solutions is positioned to address the ever-changing needs of the healthcare industry, offering solutions that not only meet regulatory requirements but also enhance patient outcomes worldwide.